2024
Ke Cen, Jiajing Bao, Xudong Wang, Hailong Tian, Yun Wang, and Jinghan Gui,* Bioinspired Divergent Synthesis of Aspersteroids A and B. (K.C. and J.B. contributed equally)
J. Am. Chem. Soc. 2024, 146, 6481−6486.
Hanxin Song, Zeliang Zhang, Chunyang Cao,* Zhijun Tang,* Jinghan Gui* and Wen Liu,* Biocatalytic Steroidal 9α-Hydroxylation and Fragmentation Enable the Concise Chemoenzymatic Synthesis of 9,10-Secosteroids. (H.S. and Z.Z. contributed equally)
Angew. Chem. Int. Ed. 2024, 63, e202319624.
Liangcai Yao, Jiajing Bao, Yun Wang, and Jinghan Gui,* Titanium-Mediated Dehydroxylative Cross-Coupling of Allylic Alcohols with Electron-Deficient Olefins.
Org. Lett. 2024, 26, 1243–1248.
Yu Wang and Jinghan Gui,* Bioinspired Skeletal Reorganization Approach for the Synthesis of Steroid Natural Products.
Acc. Chem. Res. 2024, 57, 568–579.
Zeliang Zhang, Xiao Qian, Yucheng Gu and Jinghan Gui,* Controllable skeletal reorganizations in natural product synthesis.
Nat. Prod. Rep. 2024, 41, 251–272.
Yuhan Ning, Yun Wang, and Jinghan Gui,* Bioinspired Two-Phase Synthesis of Gibbosterol A.
2023
Ganlin Huang, and Jinghan Gui,* Nature-Inspired Asymmetric Rearrangement of Cyclopropylcarbinyl Cation. (a highlight in Chinese)
Xudong Wang, Ganlin Huang, Yun Wang, and Jinghan Gui,* Asymmetric Total Synthesis of the Rearranged Steroid Phomarol Enabled by a Biomimetic SN2′ Cyclization. (X.W. and G.H. contributed equally)
J. Am. Chem. Soc. 2023, 145, 9354–9363.
• Highlighted by Org. Chem. Highlights 2023, October 30.
2022
Mengqing Zhang, Huafang Fan,* Yun Wang, and Jinghan Gui,* Total Synthesis of the Phenolic Steroid Myrmenaphthol A.
Org.Lett. 2022, 24, 7383–7387.
Peicheng Yang, Yan-Yu Li, Hailong Tian, Gan-Lu Qian, Yun Wang, Xin Hong,* and Jinghan Gui,* Syntheses of Bufospirostenin A and Ophiopogonol A by a Conformation-Controlled Transannular Prins Cyclization. (P.Y. and Y.L. contributed equally)
J. Am. Chem. Soc. 2022, 144, 17769–17775.
• Highlighted by Synfacts 2022, 18, 1277.
• Highlighted by Org. Chem. Highlights 2023, September 11.
Liangcai Yao, Jinghan Gui,* Application of the Radical Polyene Cyclization Reaction in Natural Product Synthesis. (a review in Chinese)
Chin. J. Org. Chem. 2022, 42, 2703–2714.
Yinlong Miao, Xinghui Li, Mengqing Zhang, Huafang Fan,* and Jinghan Gui,* Synthesis of 9,11-Secosteroids Pinnisterol E, Glaciasterol B, and 6-Keto-aplidiasterol B. (Y.M. and X.L. contributed equally)
Org. Lett. 2022, 24, 1684–1688.
2021
Yu Wang, Hailong Tian, and Jinghan Gui,* Gram-Scale Synthesis of Bufospirostenin A by a Biomimetic Skeletal Rearrangement Approach.
Wei Ju, Xudong Wang, Hailong Tian, and Jinghan Gui,* Asymmetric Total Synthesis of Clionastatins A and B. (W.J. and X.W. contributed equally)
J. Am. Chem. Soc. 2021, 143, 13016–13021.
• Highlighted by Synfacts 2021, 17, 1175.
• Highlighted by ChemistryViews 2021, August 24.
Xinghui Li, Zeliang Zhang, Huafang Fan, Yinlong Miao, Hailong Tian, Yucheng Gu, and Jinghan Gui,* Concise Synthesis of 9,11-Secosteroids Pinnigorgiols B and E. (X.L. and Z.Z. contributed equally)
J. Am. Chem. Soc. 2021, 143, 4886–4890.
• Highlighted by Synfacts 2021, 17, 0724.
Yuhan Ning, Hailong Tian, and Jinghan Gui,* Biogenesis-Guided Synthesis and Structural Revision of Sarocladione Enabled by Ruthenium-Catalyzed Endoperoxide Fragmentation.
Angew. Chem. Int. Ed. 2021, 60, 11222–11226 (VIP).
2020
Yu Wang, Bo Chen, Xubiao He, and Jinghan Gui,* Development of Biomimetic Synthesis of Propindilactone G.
Chin. J. Chem. 2020, 38, 1339–1352.
Yu Wang, Bo Chen, Xubiao He, and Jinghan Gui,* Bioinspired Synthesis of Nortriterpenoid Propindilactone G. (Y.W. and B.C. contributed equally)
J. Am. Chem. Soc. 2020, 142, 5007–5012.
• Top 20 most read articles for the previous 30 days, 03/2020.
Jiachen Deng, Yuhan Ning, Hailong Tian, and Jinghan Gui,* Divergent Synthesis of Antiviral Diterpenes Wickerols A and B.
J. Am. Chem. Soc. 2020, 142, 4690–4695.
• Highlighted by Org. Chem. Highlights 2020, March 30.
Jiajing Bao, Hailong Tian, Peicheng Yang, Jiachen Deng, and Jinghan Gui,* Modular Synthesis of Functionalized Butenolides by Oxidative Furan Fragmentation. (J.B. and H.T. contributed equally)
Eur. J. Org. Chem. 2020, 339–347.
2019
Yu Wang, Wei Ju, Hailong Tian, Suyun Sun, Xinghui Li, Weisheng Tian, and Jinghan Gui,* Facile Access to Bridged Ring Systems via Point-to-Planar Chirality Transfer: Unified Synthesis of Ten Cyclocitrinols.
J. Am. Chem. Soc. 2019, 141, 5021–5033.
• Highlighted by
Org. Chem. Highlights 2019, December 30.
Jiachen Deng, Jinghan Gui,* Alkyne-Forming Furan Fragmentation: A General Method to Convert Furans into Alkynoic Acids.
Synlett, 2019, 30, 642–646.
2018
Yu Wang, Wei Ju, Hailong Tian, Weisheng Tian and Jinghan Gui,* Scalable Synthesis of Cyclocitrinol.
J. Am. Chem. Soc. 2018, 140, 9413–9416.
• Top 20 most read articles for the previous 30 days, 07/2018;
• Highlighted by Synfacts 2018, 14, 1004.
Jiachen Deng, Jingjing Wu, Hailong Tian, Jiajing Bao, Yong Shi, Weisheng Tian* and Jinghan Gui,* Alkynes From Furans: A General Fragmentation Method Applied to the Synthesis of the Proposed Structure of Aglatomin B. (J.D. and J.W. contributed equally)
Angew. Chem. Int. Ed. 2018, 57, 3617–3621.
• Highlighted by
Org. Chem. Highlights 2018, October 22.
Supervised work
Julian C. Lo, Dongyoung Kim, Chung-Mao Pan, Jacob T. Edwards, Yuki Yabe, Jinghan Gui, Tian Qin, Sara Gutierrez, Jessica Giacoboni, Myles W. Smith, Patrick L. Holland and Phil S. Baran,* Fe-Catalyzed C-C Bond Construction from Olefins via Radicals.
J. Am. Chem. Soc. 2017, 139, 2484–2503.
Jinghan Gui, Chung-Mao Pan, Ying Jin, Tian Qin, Julian C. Lo, Bryan J. Lee, Steven H. Spergel, Michael E. Mertzman, William J. Pitts, Thomas E. La Cruz, Michael A. Schmidt, Nitin Darvatkar, Swaminathan R. Natarajan and Phil S. Baran,* Practical olefin hydroamination with nitroarenes.
Science 2015, 348, 886–891.
Julian C. Lo,† Jinghan Gui,† Yuki Yabe, Chung-Mao Pan and Phil S. Baran,* Functionalized olefin cross-coupling to construct carbon-carbon bonds.
Jinghan Gui, Qianghui Zhou, Chung-Mao Pan, Yuki Yabe, Aaron C. Burns, Michael R. Collins, Martha A. Ornelas, Yoshihiro Ishihara and Phil S. Baran,* C-H Methylation of Heteroarenes Inspired by Radical SAM Methyl Transferase.
J. Am. Chem. Soc. 2014, 136, 4853–4856.
Jinghan Gui, Yun Wang, Hailong Tian, Yuqi Gao and Weisheng Tian,* Perfluoroalkylsulfonyl fluoride-mediated abnormal Beckmann rearrangement of steroid 17-oximes with acid-labile groups.
Tetrahedron Lett. 2014, 55, 4233–4235.
Qianghuim Zhou, Jinghan Gui, Chung-Mao Pan, Earl Albone, Xin Cheng, Edward M. Suh, Luigi Grasso, Yoshihiro Ishihara and Phil S. Baran,* Bioconjugation by Native Chemical Tagging of C-H Bonds.
J. Am. Chem. Soc. 2013, 135, 12994–12997.
Jinghan Gui,* Hailong Tian and Weisheng Tian,* Synthesis of Glaucogenin D, a Structurally Unique Disecopregnane Steroid with Potential Antiviral Activity.
Org. Lett. 2013, 15, 4802–4805.
Shunji Zhang, Huaide Dong, Jinghan Gui and Weisheng Tian,* Stereoselective synthesis of the insect growth regulator (S)-(+)-hydroprene through Suzuki-Miyaura cross-coupling.
Tetrahedron Lett. 2012, 53, 1882–1884.
Jinghan Gui, Dahai Wang and Weisheng Tian,* Biomimetic Synthesis of 5,6-dihydro-glaucogenin C: Construction of the Disecopregnane Skeleton by Iron(II)-Promoted Fragmentation of an alpha-Alkoxy Hydroperoxide.
Angew. Chem. Int. Ed. 2011, 50, 7093–7096.
Yimin Hu,* Yuan Qu, Fenghua Wu, Jinghan Gui, Yun Wei, Qiong Hu and Shaowu Wang,* Tuned C-H Functionalization to Construct Aza-Podophyllotoxin/Aza-Conidendrin Derivatives by Means of Domino Cyclization.
Chem. Asia. J. 2010, 5, 309–314.